PJ34 hydrochloride

SKU: orb1225243

Description

PJ34 hydrochloride is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.

Key Properties

• CAS Number: 344458-15-7
• MW: 311.8
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₈ClN₃O₂
• SMILES: CN(C)C(=O)CC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1
• Target: PARP
• Solubility: Water: 66 mg/mL (198.91 mM); DMSO: 66 mg/mL (198.91 mM)

Bioactivity

• In Vivo:
  To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.
• In Vitro:
  PJ34 inhibits the PARP enzyme activity with an IC50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10-7 to 10-5 M.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PARP