Pitavastatin

SKU: orb1984328

Description

Pitavastatin (NK-104) is a potent HMG-CoA reductase inhibitor that lowers cholesterol by inducing hepatic LDL receptor expression and exhibits neuroprotective properties. It is widely used in research models of hypercholesterolemia, atherosclerosis, and acute coronary syndromes to study its effects on lipid metabolism and oxidative stress in vitro and in vivo.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 147511-69-1
• MW: 421.46
• Purity: 97.17% (May vary between batches)
• Formula: C₂₅H₂₄FNO₄
• SMILES: C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C1=C(C2=C(N=C1C3CC3)C=CC=C2)C4=CC=C(F)C=C4
• Target: HMG-CoA Reductase,Mitophagy,Apoptosis,Autophagy
• Solubility: DMSO:33.13 mg/mL (78.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.83 mM)

Bioactivity

• In Vivo:
  In 4-week-old female NCR Nu/Nu nude mice bearing Ovcar-4 tumors, Pitavastatin (administered at a dose of 59 mg/kg; orally (p.o.); twice daily for 28 days) is able to significantly induce tumor regression.
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• In Vitro:
  Pitavastatin inhibits the growth of a panel of ovarian cancer cells, including those likely representing HGSOC, with IC50 values of 0.4-5 μM in monolayers and 0.6-4 μM in spheroids . At 1 μM for 48 hours, Pitavastatin induces apoptosis in Ovcar-8 and Ovcar-3 cells, increasing the activity of caspases-3, -7, -8, and -9, and results in PARP cleavage in Ovcar-8 cells, as evidenced by Western Blot analysis [1, 4].
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pitavastatin, Compound T7072, Autophagy, Apoptosis, Mitophagy, NK104, NK-104, NK 104, HMGCoAReductase, HMG-CoA Reductase (HMGCR), HMGCoA Reductase

Compound Identifiers

PubChem CID

5282452