Pirarubicin

SKU: orb1300604

Description

Pirarubicin

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 72496-41-4
• MW: 627.64
• Purity: 99.15%
• Formula: C₃₂H₃₇NO₁₂
• SMILES: COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O[C@@H]6CCCCO6)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• Target: Antibiotic,Topoisomerase,Antibacterial,Autophagy
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:6.32 mg/mL (10.07 mM)

Bioactivity

• In Vivo:
  Pirarubicin reduce the tumor weight to 60% o the control level in M5076 solid tumor-bearing mice, although doxorubicin has no effect. Pirarubicin and Epirubicin are effective against V x 2 tumor when injected vi the hepatic intra-arterial (h.i.a.) route the activity of Pirarubicin is stronger than that of Epirubicin.
• In Vitro:
  Pirarubicin is rapidly taken up by M5076 cells an the intracellular concentration of pirarubicin reaches more than 2.5-fold that of doxorubicin. Pirarubicin is more effective than doxorubicin in terms o the 50% cell growth inhibitory concentration in vitro Pirarubicin causes G0/G1 cell cycle arrest in MG-63 cells. Pirarubicin suppresse the expression of PCNA, cyclin D1, cyclin E and Bcl-2, and increases Bax expression in MG-63 cells. Pirarubicin markedly relaxes contractions induced by noradrenaline (0.1 μM) in the aorta with endothelium, but not in that without endothelium. Pirarubicin-induced relaxation is inhibited by methylene blue (5 μM), hydroquinone (100 μM), phenidone 50 μM), haemoglobin (1 μM) and p-bromophenacyl bromide 50 μM), but not by indomethacin (25 μM). Pirarubicin is approximately 2-5 times more potent than Adriamycin in SKUT1B, HEC1A, and BG1 cell lines. Pirarubicin also displays a reverse dose-response pattern of G2 block so that at high dose, cell cycle kinetics would mirror those of untreated controls.

Storage & Handling

• Storage: Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Antibiotic, Bacterial, Autophagy, inhibit, Inhibitor, Pirarubicin, Topoisomerase, Topo II, Theprubicin, THP

Compound Identifiers

PubChem CID

11296583