Piperoxan hydrochloride

SKU: orb1302786

Description

Piperoxan hydrochloride, also known as Benodaine, is a selective α2-adrenoceptor antagonist. It holds historical significance as the first discovered antihistamine and is utilized in pharmacological research to study adrenergic signaling pathways in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 135-87-5
• MW: 269.77
• Purity: 99.61%
• Formula: C₁₄H₂₀ClNO₂
• SMILES: Cl.C(C1COc2ccccc2O1)N1CCCCC1
• Target: Adrenergic Receptor
• Solubility: DMSO:50 mg/mL (185.34 mM)

Bioactivity

• In Vitro:
  When superfusing the medulla with Piperoxan (50 μM; 5 min) and the pons with artificial cerebrospinal fluid (ACSF), three inactive preparations exhibit low-frequency rhythmic phrenic bursts (2-4 c/min), with the phrenic burst frequency in 12 active preparations significantly increasing to 163±12% of the previous average frequency in the final 3 minutes of Piperoxan application. In active preparations, the impact of norepinephrine (NA) applications (25 μM; 5 min) is assessed under conditions of superfusion with either ACSF (n=8) or α2 adrenoceptor antagonist Piperoxan (50 μM; PIP-ACSF; n=5). Both scenarios of NA application (NA-ACSF alone or combined with PIP-ACSF+NA) lead to a marked increase in phrenic burst frequency. Notably, inhibiting medullary α2 adrenoceptors with Piperoxan significantly enhances this effect: during NA application's fifth minute, phrenic burst frequency escalates to 171±11% with ACSF alone and 234±21% under PIP-ACSF, compared to the baseline control values.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

dl-Piperoxan hydrochloride, Benodaine, Benodaine hydrochloride, AdrenergicReceptor, Adrenergic Receptor, Piperoxan, α2 receptor

Compound Identifiers

PubChem CID

101619