Piperoxan hydrochloride

SKU: orb1226453

Description

An α-adrenergic blocking agent and antihistamine; also antagonizes histamine-induced bronchospasm in vivo.

Key Properties

• CAS Number: 135-87-5
• MW: 269.7671
• Purity: >98% (HPLC)
• Formula: C₁₄H₂₀ClNO₂
• SMILES: C1CCN(CC1)CC2COC3=CC=CC=C3O2.Cl
• Target: Adrenergic Receptor
• Solubility: DMSO: ≥ 31mg/mL

Bioactivity

• In Vitro:
  When the medulla is superfused with α2 adrenoceptor antagonist Piperoxane (50 μM; 5 min) while the pons is with artificial cerebrospinal fluid (ACSF), the three inactive preparations display rhythmic phrenic bursts at a low frequency (2-4 c/min), and the phrenic burst frequency of the 12 active ones significantly increases during the last 3 min of Piperoxane applications (163±12% of the previous mean frequency). In active medullary preparations, the effects of NA applications (25 μM; 5 min) are compared when the preparations sre superfused either by ACSF (n=8) or by the α2 adrenoceptor antagonist Piperoxane (50 μM; PIP-ACSF; n=5). NA applications either alone (NA-ACSF) or with Piperoxane (PIP-ACSF+NA) significantly increases the phrenic burst frequency. However, the blockage of the medullary α2 adrenoceptors by Piperoxane potentiates a phrenic burst frequency increase: during the fifth minute of NA applications, the phrenic burst frequency reached 171±11% of the mean control value when ACSF is applied alone and 234±21% of the mean control value when PIP-ACSF is applied in control condition.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

F 933 | 933F | Benodaine

Quick Database Links

Gene Symbol

Adrenergic Receptor