Piperlongumine

SKU: orb1300321

Description

Piperlongumine (Piplartine) is a bioactive alkaloid with demonstrated anti-tumor properties, primarily through the induction of reactive oxygen species (ROS) and apoptosis. It is widely used in cancer research, showing efficacy in both in vitro cell culture and in vivo xenograft models for studying oxidative stress-mediated cell death.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 20069-09-4
• MW: 317.34
• Purity: >98%
• Formula: C₁₇H₁₉NO₅
• SMILES: COc1cc(\C=C\C(=O)N2CCC=CC2=O)cc(OC)c1OC
• Target: Glutathione
• Solubility: Soluble in DMSO (up to 25 mg/ml).

Bioactivity

• In Vivo:
  Piperlongumine (50 mg/kg i.p.) causes in vivo growth inhibition of tumor cells without leading to major changes in the biochemical, hematological and histopathological parameters.
• In Vitro:
  Piperlongumine is a known ROS inducer which could induce pancreatic cancer cell death in cell culture As a thromboxane A(2) receptor antagonist, Piperlongumine inhibits platelet aggregation. Piperlongumine also promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death.
• Cell Research:
  MCF-7 and 786-O cells are incubated with various PL concentrations for 48h. Cell proliferation is analysed by CellTiter Blue assay. Effective doses (ED) are calculated using XLift, Microsoft Excel add-in. (Only for Reference)

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Autophagy, Bacterial, inhibit, Ferroptosis, ERK, Extracellular signal regulated kinases, Inhibitor, ROS, ReactiveOxygenSpecies, Reactive Oxygen Species, Piperlongumine, Piplartine, PPLGM

Compound Identifiers

PubChem CID

637858