Piperacillin sodium salt

SKU: orb1224534

Description

Piperacillin is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59703-84-3
• MW: 539.54
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₆N₅NaO₇S
• SMILES: CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]
• Target: Antibiotic
• Solubility: Ethanol: 100 mg/mL (185.34 mM); Water: 100 mg/mL (185.34 mM); DMSO: 100 mg/mL (185.34 mM)

Bioactivity

• In Vivo:
  Animal model: BALB/c low inoculum model of K. pneumoniae, KEN-11 strain. Dosage: 100 mg/kg. Administration: Intravenous injection (i. v.), 4 times a day, 5 d, in combination with Tazobactam (12.5 mg/kg, i. v. , 4 times a day, 5 d). Result: Enabled all mice survived whereas all control mice died by 5 d, decreased the number of bacteria in lungs compared with control group[. Observed no bacteria in the blood of most mice (except for two mice at the early phase) while bacteria were observed in the blood of control group. Observed few inflammatory cells in the alveoli whereas an influx of numerous inflammatory cells were observed in the control group.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CL 227,193 | T-1220

Quick Database Links

Gene Symbol

Antibiotic