PIN1 degrader-1

SKU: orb2945881

Description

PIN1degrader-1 (Compound 158H9) is a potent, covalent Pin1 inhibitor (IC50=21.5 nM) that binds Cys113, triggering protein destabilization and proteasomal degradation. This molecule is a valuable chemical probe for studying Pin1 biology in cancer research, demonstrating anti-proliferative effects in various cancer cell lines in vitro.

Key Properties

• MW: 611.519
• Formula: C₃₀H₃₂Cl₂N₆O₄
• SMILES: C1CCN([C@@H](C1)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N)C(=O)[C@H](CC4=CNC5=C4C=CC(=C5)Cl)NC(=O)CCl
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676802