Pimodivir

SKU: orb1302907

Description

Pimodivir (VX-787) is an orally administered small molecule inhibitor that selectively targets the PB2 subunit of the influenza A virus polymerase complex. It has demonstrated potent antiviral activity in both in vitro assays and in vivo animal models, making it a valuable tool for researching influenza pathogenesis and novel therapeutic strategies.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1629869-44-8
• MW: 399.39
• Purity: 99.99% (May vary between batches)
• Formula: C₂₀H₁₉F₂N₅O₂
• SMILES: OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12
• Target: Influenza Virus
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.01 mM);DMSO:50 mg/mL (125.19 mM)

Bioactivity

• In Vivo:
  In mouse influenza model,Pimodivir (1, 3, or 10 mg/kg, bid) provided complete survival. Pimodivir (2, 6, and 20 mg/kg/day, p.o.) completely prevent death in the H1N1pdm virus infection in mice.
• In Vitro:
  Pimodivir is very potent against influenza A strains,and shows potent activity against all influenza A virus strains tested, with an EC50 range of 0.13 to 3.2 nM.
• Cell Research:
  Pimodivir is dissolved in DMSO.The compound cytotoxicity and efficacy testing is performed in 96-well plates with macrophages at 95% confluence. The compounds are added to the medium, and 30 min later, the cells are infected with virus or non-infected. The cell viability is analyzed with the Cell Titer Glo assay at 24 hpi. The luminescence is read with a PHERAstar FS plate reader.
• Animal Research:
  The mice, infected intranasally with influenza virus, are given Pimodivir(prepared in 0.5% methylcellulose) twice a day.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Influenza A polymerases, Influenza Virus, InfluenzaVirus, Inhibitor, VX-787, Pimodivir, VX 787, VX787

Compound Identifiers

PubChem CID

67286591