Pimodivir tosylate

• Catalog Number: orb1739273
• Category: Small Molecules
• Description: Pimodivir tosylate
• Purity: 98.00%
• MW: 571.6
• Biological Activity: Pimodivir, also known as VX-787, JNJ-872, is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. VX-787 binds the cap-binding domain of the PB2 subunit with a KD (dissociation constant) of 24 nM as determined by isothermal titration calorimetry (ITC). The cell-based EC50 (the concentration of compound that ensures 50% cell viability of an uninfected control) for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay, with a similar EC50 in a viral RNA replication assay. VX-787 is active against a diverse panel of influenza A virus strains, including H1N1pdm09 and H5N1 strains, as well as strains with reduced susceptibility to neuraminidase inhibitors (NAIs).
• CAS Number: 1777814-27-3
• Formula: C₂₇H₂₇F₂N₅O₅S
• SMILES: Cc1ccc(cc1)S(O)(=O)=O.OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12
• Storage: -20°C
• Note: For research use only