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Pim-1 kinase inhibitor 5

SKU: orb2278266

Description

This small molecule Pim-1 kinase inhibitor (Compound 4c) demonstrates potent enzymatic inhibition (IC50 = 0.61 µM) and exhibits cytotoxic activity against a panel of human cancer cell lines, including HepG2, MCF-7, PC3, and HCT-116, with IC50 values from 6.95 to 20.19 µM. It is a useful research tool for studying Pim-1 kinase signaling in oncology and cell proliferation, applicable in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2928606-67-9
MW406.26
FormulaC22H13Cl2N3O
SMILESC(#N)C=1C(=CC(=NC1Cl)C2=CC=C(OC)C=C2)C3=CC4=C(N=C3Cl)C=CC=C4
TargetPim

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information