Pifithrin-α, p-Nitro, Cyclic

SKU: orb1217825

Description

Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form inhibitor of p53.

Key Properties

• CAS Number: 60477-38-5
• MW: 299.35
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₃N₃O₂S
• SMILES: C1CCC2=C(C1)N3C=C(N=C3S2)C4=CC=C(C=C4)[N+](=O)[O-]
• Target: p53
• Solubility: DMSO:5 mg/mL (16.70 mM; Need ultrasonic);DMF:12.5 mg/mL (41.76 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Intraocular injection of pifithrin-α slightly increases survival of retinal ganglion cell (RGC) at the concentration of 6 μM but not at 0.06 μM. Pifithrin-α, p-Nitro, Cyclic (PFN-α) is not effective In vivo, even at 6 μM. Pifithrin-α, p-Nitro, Cyclic shows the half-life (t1/2) of 6 hours (when incubated in biological conditions).
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• In Vitro:
  Pifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PFN-α

Quick Database Links

Gene Symbol

p53