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PIAS1 (C1) Antibody, Rabbit Polyclonal
Catalog Number: orb67013
| Catalog Number | orb67013 |
|---|---|
| Category | Antibodies |
| Description | Rabbit polyclonal to PIAS1.E3 SUMO-protein ligase PIAS1 is a member of the mammalian PIAS (protein inhibitor of activatedSTAT-1 (signal transducer and activator of transcription-1)) family, which contains a putative zincbindingmotif and a highly acidic region. PIAS1 functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMOtetheringfactor. PIAS1 plays a crucial role as a transcriptional coregulation in various cellularpathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.In vitro, PIAS1 binds A/T-rich DNA. The effects of the transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context. |
| Species/Host | Rabbit |
| Clonality | Polyclonal |
| Tested applications | WB |
| Reactivity | Mouse |
| Immunogen | C-terminal region of mouse PIAS1 |
| Dilution range | WB:1:1000-1:5000 |
| Purity | Affinity purification |
| Conjugation | Unconjugated |
| MW | 72 |
| UniProt ID | O75925 |
| Storage | -20°C |
| Buffer/Preservatives | 0.01% NaN3 |
| Alternative names | anti-PIAS1 antibody,anti-E3 SUMOprotein ligase PIA Read more... |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Western blot analysis of total cell extracts from mouse thymus using PIAS1 antibody
