PIAS1 (C) Antibody, Rabbit Polyclonal

SKU: orb67014

Description

Rabbit polyclonal to PIAS1.E3 SUMO-protein ligase PIAS1 is a member of the mammalian PIAS (protein inhibitor of activatedSTAT-1 (signal transducer and activator of transcription-1)) family, which contains a putative zincbindingmotif and a highly acidic region. PIAS1 functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMOtetheringfactor. PIAS1 plays a crucial role as a transcriptional coregulation in various cellularpathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.In vitro, PIAS1 binds A/T-rich DNA. The effects of the transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context.

Research Area

Epigenetics

Images & Validation

• Tested Applications: IF, IHC, IP, WB
• Dilution Range: WB:1:1000-1:5000,IP:1:50-1:100,IF:1:100-1:200,IHC:1:100-1:200
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human PIAS1
• Molecular Weight: 72
• Purity: antiserum
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-PIAS1 antibody,anti-E3 SUMOprotein ligase PIAS1 antibody,anti-DEAD antibody,anti-H boxbinding protein 1 antibody,anti-Protein inhibitor of activated STAT protein 1 antibody,anti-DDXBP1 antibody,anti-GBP antibody,anti-RNA helicase IIbinding protein antibody,anti-GU antibody,anti-RHII antibody,anti-zinc finger antibody,anti-MIZtype containing 3 antibody,anti-ZMIZ3 antibody,anti-Gubinding protein antibody,anti-AR interacting protein antibody

Western blot analysis of total cell extracts from mouse thymus using PIAS1 antibody

Western blot analysis of total cell extracts from ias1-plus or Pias1-minus mouse thymus using PIAS1 antibody

Quick Database Links

UniProt

O88907