PI3K/AKT-IN-1

SKU: orb1687045

Description

PI3K/AKT-IN-1

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3033069-84-7
• MW: 465.53
• Purity: 99.84% (May vary between batches)
• Formula: C₂₃H₂₃N₅O₄S
• SMILES: N#CC=1C(=NC(=NC1C=2C=CC(OC)=CC2)SC)NN=CC3=CC(OC)=C(OC)C(OC)=C3
• Target: Akt,PI3K,Apoptosis
• Solubility: DMSO:40 mg/mL (85.92 mM)

Bioactivity

• Target IC50:
  PI3Kγ:6.99 μM|Akt:3.36 μM|PI3Kδ:4.01 μM
• In Vivo:
  The median lethal dose (LD50) of PI3K/AKT-IN-1 was greater than the test dose of 2000 mg/kg, indicating that PI3K/ AKt-in-1 was non-toxic and well tolerated by experimental animals.
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• In Vitro:
  PI3K/AKT-IN-1 showed excellent cytotoxic activity in breast cancer MCF-7 and leukemia K562 cell lines with IC50 values of 3.22 μM and 2.62 μM, respectively. PI3K/AKT-IN-1 causes the cell cycle to stall in the S phase, leading to apoptosis induced by caspase 3 activation of leukemia (k562) cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171324541