ALK/PI3K/AKT-IN-1

SKU: orb3028816

Description

ALK/PI3K/AKT-IN-1 (Compound 45) effectively inhibits the proliferation of cancer cell lines A549, H1975, and PC9, with IC50 values of 0.44, 0.83, and 1.51 μM, respectively. This compound enhances the expression of p21 and p27, and decreases the activity of CDK2 and p-Rb, causing cell cycle arrest at the G1 phase. It suppresses the ALK/PI3K/AKT signaling pathway, promotes mitochondrial membrane potential depolarization, and induces apoptosis in A549 cells. Furthermore, ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheres.

Research Area

Cardiovascular Research, Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 3050831-84-7
• MW: 473.522
• Formula: C₂₅H₂₀FN₅O₂S
• SMILES: O=C(NC1=NC=2C=C(C=CC2S1)C=3C=CC=4N=CN(C(=O)C4C3)CCC)NC5=CC=C(F)C=C5
• Target: Mitochondrial Metabolism,Akt,PI3K,Apoptosis,ALK,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Mitochondrial Metabolism,Akt,PI3K,Apoptosis,ALK,CDK