PI-828

SKU: orb2901590

Description

PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.

Key Properties

• CAS Number: 942289-87-4
• MW: 322.36
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈N₂O₃
• SMILES: Nc1ccc(cc1)-c1cccc2c1oc(cc2=O)N1CCOCC1
• Target: PI3K
• Solubility: In Vitro: DMSO : ≥ 12.5 mg/mL (38.78 mM)

Bioactivity

• In Vitro:
  PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells. PI-828 (0.78-3.12 μM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis. Cell Viability Assay Cell line: 4T1 breast cancer cells and 4306 ovarian cancer cells. Concentration: 0.01, 0.1, 1, 10 and 100 μM Incubation time: Result: Exhibited cytotoxic effect. Apoptosis Analysis Cell line: Human embryonic carcinoma NCCIT cells. Concentration: 0.78, 1.56, 3.12, 6.25, 12.5 μM Incubation time: 48 hours. Result: Concentrations of ranging from 0.78 to 3.12 μM decreased caspase 3 activation; higher concentrations caused apoptosis.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K