PI-828

SKU: orb1706792

Description

PI-828

Research Area

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 942289-87-4
• MW: 322.36
• Purity: 99.95%
• Formula: C₁₉H₁₈N₂O₃
• SMILES: Nc1ccc(cc1)-c1cccc2c1oc(cc2=O)N1CCOCC1
• Target: Casein Kinase,PI3K
• Solubility: DMSO:11.2 mg/mL (34.74 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.1 mM)

Bioactivity

• Target IC50:
  CK2α2:1.127 μM|CK2:149 nM|p110α:173 nM
• In Vitro:
  PI-828 (0.78-3.12 µM; 48 hours) reduces caspase 3 activation. However, higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis.The sensitivity to PI-828 is a key feature of PI3K-C2β that shows a different sensitivity to this inhibitor compared to class I PI3Ks. Of note, 1 μM PI-828 has no effect on the activity of PI3K-C2β, while it significantly inhibits class I PI3Ks. In particular, a concentration of 10 μM PI-828 completely blocks class I PI3Ks, whereas it has only a partial inhibitory effect on PI3K-C2β

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CK2α2, CK2, CaseinKinase, Casein Kinase, p110α, LY-294002, 4gamma-NH2, LY294002, LY 294002, 4gamma-NH2, PI 828, PI828, PI-828

Compound Identifiers

PubChem CID

25181195