PI-828

SKU: orb1706792

Description

PI-828 is a selective PI3K inhibitor widely employed in biochemical and cell biology research to investigate PI3K signaling pathways. It has been utilized in both in vitro and in vivo studies to explore mechanisms in oncology, metabolism, and stem cell biology, where it promotes mesodermal differentiation.

Research Area

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 942289-87-4
• MW: 322.36
• Purity: 99.39% (May vary between batches)
• Formula: C₁₉H₁₈N₂O₃
• SMILES: Nc1ccc(cc1)-c1cccc2c1oc(cc2=O)N1CCOCC1
• Target: PI3K,Casein Kinase
• Solubility: DMSO:11.2 mg/mL (34.74 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.1 mM)

Bioactivity

• Target IC50:
  CK2α2:1.127 μM|CK2:149 nM|p110α:173 nM
• In Vitro:
  PI-828 (0.78-3.12 µM; 48 hours) reduces caspase 3 activation. However, higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis.The sensitivity to PI-828 is a key feature of PI3K-C2β that shows a different sensitivity to this inhibitor compared to class I PI3Ks. Of note, 1 μM PI-828 has no effect on the activity of PI3K-C2β, while it significantly inhibits class I PI3Ks. In particular, a concentration of 10 μM PI-828 completely blocks class I PI3Ks, whereas it has only a partial inhibitory effect on PI3K-C2β
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CK2α2, CK2, CaseinKinase, Casein Kinase, p110α, LY-294002, 4gamma-NH2, LY294002, LY 294002, 4gamma-NH2, PI 828, PI828, PI-828

Compound Identifiers

PubChem CID

25181195