Phospho-TrkA/B (Tyr490/Tyr516) Antibody

• Catalog Number: orb1732997
• Category: Antibodies
• Description: The family of Trk receptor tyrosine kinases consists of TrkA, TrkB and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA.
• Species/Host: Rabbit
• Clonality: Monoclonal
• Tested applications: WB
• Reactivity: Human, Mouse, Rat
• Isotype: Rabbit IgG
• Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Tyr516 of human TrkB
• Concentration: 1mg/ml
• Dilution range: WB: 1/500-1/1000
• Conjugation: Unconjugated
• MW: Calculated MW: 92 kDa; Observed MW: 140 kDa
• Entrez: 4915
• UniProt ID: Q16620
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% rAlbumin
• Alternative names: NTRK2; TRKB; BDNF/NT-3 growth factors receptor; GP
• Note: For research use only
• Expiration Date: 12 months from date of receipt.