Phospho-JNK (Thr183/Tyr185) Antibody

• Catalog Number: orb1730565
• Category: Antibodies
• Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: ELISA, ICC, IHC, WB
• Reactivity: Gallus, Human, Mouse, Rat
• Isotype: Rabbit IgG
• Immunogen: The antiserum was produced against synthesized peptide derived from human JNK1/2/3 around the phosphorylation site of Thr183 and Tyr185. AA range:151-200
• Dilution range: WB: 1/500-1/1000; IHC: 1/50-1/100; ICC: 1/50-1/200; ELISA: 1/10000
• Conjugation: Unconjugated
• MW: Calculated MW: 48 kDa; Observed MW: 46,54 kDa
• Entrez: 5599
• UniProt ID: P45983
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: AI849689; c Jun N terminal kinase 1; C-JUN kinase
• Note: For research use only
• Expiration Date: 12 months from date of receipt.