Phleomycin

SKU: orb1705035

Description

Phleomycin is a glycopeptide antibiotic that induces DNA cleavage, similar to bleomycin, by binding and intercalating DNA to disrupt helix integrity. It is widely used in molecular biology and oncology research for in vitro selection of transfected cells and in vivo studies of DNA damage and repair mechanisms.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 11006-33-0
• MW: 1268.29
• Formula: C₄₈H₆₉N₁₇O₂₀S₂
• SMILES: NC1=NC(C(NCC(N)C(N)=O)CC(N)=N)=NC(C(NC(C(O[C@@]2(OC3[C@H](O)[C@@](O)(C(N)=O)[C@@H](O)C(CO)O3)[C@H](C)[C@@H](O)[C@H](O)[C@H](CO)O2)C4=CNC=N4)C(C(O)C(C)C(NC(C(C)=O)C(NCCC5=NC(C6=NC(C(N)=O)=CS6)CS5)=O)=O)=O)=O)=C1
• Target: DNA/RNA Synthesis,Antibacterial,Antibiotic
• Solubility: H2O:100 mg/mL (78.85 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phleomycin, RNASynthesis, RNA Synthesis, Antibiotic, Bacterial, DNASynthesis, DNA damage, DNA Synthesis, DNA/RNA Synthesis, DNA-cleaving, Inhibitor, inhibit, glycopeptide

Compound Identifiers

PubChem CID

163285742