Phenylbiguanide

SKU: orb1300038

Description

Phenylbiguanide is a selective agonist for the 5-HT3 receptor, exhibiting an EC50 of 3.0±0.1 μM. It is widely used in pharmacological research to study serotonin receptor function and modulation in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 102-02-3
• MW: 177.21
• Purity: 99.87%
• Formula: C₈H₁₁N₅
• SMILES: N(C(NC(=N)N)=N)C1=CC=CC=C1
• Target: 5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (22.57 mM);DMSO:150 mg/mL (846.45 mM)

Bioactivity

• Target IC50:
  5-HT3:3 μM (EC50)
• In Vivo:
  Phenylbiguanide (PBG) is a drug known to stimulate cardiopulmonary afferent C-fibres. PBG is injected into the right atrium of the heart in anaesthetised mice and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Serotonin Receptor, Phenylbiguanide, PBG, inhibit, N-Phenylbiguanide, Inhibitor, 5-HT3, 5-HT Receptor, 5HT Receptor, 5-hydroxytryptamine Receptor, 5HTReceptor, 1-Phenylbiguanide

Compound Identifiers

PubChem CID

4780