Phenylbiguanide

SKU: orb1220548

Description

Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).

Key Properties

• CAS Number: 102-02-3
• MW: 177.21
• Purity: >98% (HPLC)
• Formula: C₈H₁₁N₅
• SMILES: NC(=N)NC(=N)Nc1ccccc1
• Target: 5-HT Receptor
• Solubility: DMSO:150 mg/mL (846.45 mM)

Bioactivity

• In Vivo:
  In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres, is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.
• In Vitro:
  Phenylbiguanide (1-Phenylbiguanide) is a 5-HT3 receptor selective agonist with pEC50s of 5.57, 4.07, and 4.47 for r5-HT3A(b), h5-HT3A, m5-HT3A(b), respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

N-Phenylbiguanide | PBG | 1-Phenylbiguanide

Quick Database Links

Gene Symbol

5-HT Receptor