Phenazopyridine hydrochloride

SKU: orb1226444

Description

Phenazopyridine hydrochloride is a local analgesic that has been used in urinary tract disorders.

Key Properties

• CAS Number: 136-40-3
• MW: 249.7
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₂ClN₅
• SMILES: C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N.Cl
• Target: Sodium Channel
• Solubility: DMSO: 50 mg/mL (200.24 mM)

Bioactivity

• In Vivo:
  Animal model: C57BL/6 mice model of Alzheimer's disease. Dosage: 15 mg/kg. Administration: Intraperitoneal injection (i.p.); Once daily for 2 weeks. Result: Increased the RPS23RG1 levels in lungs, liver and kidneys of mice. Animal model: APP/PS1 mice model of Alzheimer's disease. Dosage: 15 mg/kg. Administration: Intracerebroventricularly injection; Once daily for 2 weeks. Result: Significantly reduced amyloid plaques. Increased protein levels of RPS23RG1, PSD-95, and phosphorylated/inactivated GSK-3β, though without affecting levels of tau, phosphorylated tau, and p35.
• In Vitro:
  Cell Differentiation Assay. Cell line: Human ES cells. Concentration: 3 μM. Incubation time: 6 weeks. Result: After 10 weeks formed a neural network in the cells. RT-PCR. Cell line: Human ES cells. Concentration: 3 μM. Incubation time: 6 weeks. Result: Accelerated emergence of early neuronal markers and decreased markers of undifferentiated and non-neural cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phenazopyridine Hydrochloride | Phenazopyridine HCl

Quick Database Links

Gene Symbol

Sodium Channel