Phenazoline

SKU: orb1220358

Description

Argireline a synthetic peptide which is patterned from the N-terminal end of the protein SNAP-25 can both reduce the degree of existing facial wrinkles and demonstrate effectively against their development.

Key Properties

• CAS Number: 91-75-8
• MW: 265.35
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₉N₃
• SMILES: c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1
• Target: Others
• Solubility: DMSO:53mg/mL(199.74mM)

Bioactivity

• In Vivo:
  Antazoline (IP; 0.01 ml/g; 30min) as H1 receptor antagonists diminishes the anticonvulsant activity of carbamazepine and diphenylhydantoin. Animal model: Swiss mice. Dosage: 0.01 mL/g. Administration: Antazoline (IP; 0.01 ml/g; 30min). Result: Showed some proconvulsive activity.
• In Vitro:
  Antazoline (Phenazoline) shows good inhibitory effect on HBV DNA in the supernatant of HepAD38 and Huh7 cells with the value of EC50 is 2.910 μmol/L and 2.349 μmol/L, respectively. Cell Cytotoxicity Assay Cell line: HepAD38 cells. Concentration: 10μmol/L. Incubation time: 5 days. Result: Exhibited no significant cytotoxicity at a concentration of 10μmol/L and had a dose-dependent inhibition of HBV DNA in the supernatant. RT-PCR Cell line: Huh7 cells. Concentration: 30 μmol/L, 10 μmol/L, 3.33 μmol/L, 1.1 μmol/L, 0.370 μmol/L, and 0.123 μmol/L Incubation time: 4 days. Result: Had a significant inhibitory effect on HBV DNA in supernatants in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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