PHCCC

SKU: orb1304178

Description

PHCCC is a small molecule that acts as a positive allosteric modulator of mGluR4 and an antagonist for Group I mGluRs, mGluR2, and mGluR8. It is a research tool used in vitro and in vivo to investigate neurological disorders such as Parkinson's disease and anxiety.

Research Area

Neuroscience

Key Properties

• CAS Number: 179068-02-1
• MW: 294.3
• Purity: 99.31%
• Formula: C₁₇H₁₄N₂O₃
• SMILES: C(NC1=CC=CC=C1)(=O)C23C(C2)C(=NO)C=4C(O3)=CC=CC4
• Target: GluR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.4 mM);DMSO:55 mg/mL (186.88 mM)

Bioactivity

• Target IC50:
  mGlu (Group I):6 μM(EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

disease, allosteric, (-) PHCCC, Inhibitor, inhibit, Parkinson's, Metabotropic glutamate receptors, mGluR, mGluR1, neurons, neuroprotective, PHCCC

Compound Identifiers

PubChem CID

3579925