PHCCC

SKU: orb1223232

Description

PHCCC is a positive allosteric modulator of mGluR4. PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats. PHCCC reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors. PHCCC showed neuroprotection against betaAP- and NMDA-toxicity in mixed cultures of mouse cortical neurons. This neuroprotection was additive to that induced by the highly efficacious mGluR1 antagonist CPCCOEt and was blocked by MSOP, a group-III mGluR antagonist. Our data provide evidence for a novel pharmacological site on mGluR4, which may be used as a target-site for therapeutics.

Key Properties

• CAS Number: 179068-02-1
• MW: 294.31
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₄N₂O₃
• SMILES: C12(C(/C(=N/O)/c3ccccc3O1)C2)C(=O)Nc1ccccc1
• Target: 5-HT Receptor
• Solubility: DMSO : ≥ 32 mg/mL; 108.73 mM

Bioactivity

• In Vivo:
  PHCCC (75 nmol/2.5 μl; intracerebroventricular) produces an antiparkinsonian effect in a dopamine depletion akinesia model.
• In Vitro:
  PHCCC potentiated the effect of L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) in inhibiting transmission at the striatopallidal synapse.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PHCCC

Quick Database Links

Gene Symbol

5-HT Receptor