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PFI-4

SKU: orb1306909

Description

PFI-4

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number900305-37-5
MW380.44
Purity≥95% (May vary between batches)
FormulaC21H24N4O3
SMILESCOc1ccccc1C(=O)Nc1cc2n(C)c(=O)n(C)c2cc1N1CCCC1
TargetEpigenetic Reader Domain
SolubilityDMSO:14 mg/mL (36.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.63 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:5 mg/mL (13.14 mM)

Bioactivity

Target IC50
BRPF1:80 nM|BRPF3:>10μM|BRPF2:7.9 μM
In Vitro
PFI-4 is cell permeable, and acts by displacing the BRPF1 bromodomain from Histone H3.3.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BRPF3, BRPF2, BRPF1, bone loss, inhibit, osteoclasts, osteolytic malignant bone lesions, Inhibitor, Epigenetic Reader Domain, EpigeneticReaderDomain, PFI 4, PFI4, PFI-4

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 110.00
25 mg
$ 170.00
50 mg
$ 240.00
100 mg
$ 370.00
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