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PFI-4

SKU: orb1223713

Description

A potent, selective inhibitor of the BRPF1 bromodomain with pIC50 of 7.3; exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.

Images & Validation

Key Properties

CAS Number900305-37-5
MW380.4402
Purity>98% (HPLC)
FormulaC21H24N4O3
SMILESO=C(NC1=C(N2CCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
TargetBromodomain
SolubilityDMSO: 26 mg/mL

Bioactivity

In Vitro
PFI-4 (1.25 μM; 7 or 11 days) inhibits differentiation of human osteoclasts. Cell Viability Assay Cell line: Osteoclasts. Concentration: 1.25 μM Incubation time: 7 or 11 days. Result: Significantly reduces MMP9 secretion in osteoclasts.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PFI-4 | PFI 4 | PFI4

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Protocol Information

PFI-4 (orb1223713)

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Available Sizes

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200 mg
500 mg
5 mg
$ 110.00
10 mg
$ 130.00
25 mg
$ 240.00
50 mg
$ 430.00
100 mg
$ 730.00