PFI-4

SKU: orb1223713

Description

A potent, selective inhibitor of the BRPF1 bromodomain with pIC50 of 7.3; exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.

Key Properties

• CAS Number: 900305-37-5
• MW: 380.4402
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₄N₄O₃
• SMILES: O=C(NC1=C(N2CCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
• Target: Bromodomain
• Solubility: DMSO: 26 mg/mL

Bioactivity

• In Vitro:
  PFI-4 (1.25 μM; 7 or 11 days) inhibits differentiation of human osteoclasts. Cell Viability Assay Cell line: Osteoclasts. Concentration: 1.25 μM Incubation time: 7 or 11 days. Result: Significantly reduces MMP9 secretion in osteoclasts.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PFI-4 | PFI 4 | PFI4

Quick Database Links

Gene Symbol

Bromodomain