PFI-3

SKU: orb1300329

Description

PFI-3 is a potent and selective chemical probe targeting the bromodomains of SMARCA2/4 and PB1 proteins with a Kd of 89 nM. It is widely used in vitro and in vivo to investigate epigenetic mechanisms in oncology, particularly for studying potential therapeutic strategies in breast cancer models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1819363-80-8
• MW: 321.37
• Purity: 99.71%
• Formula: C₁₉H₁₉N₃O₂
• SMILES: [H][C@@]12CN(c3ccccn3)[C@@]([H])(CN1\C=C\C(=O)c1ccccc1O)C2
• Target: Epigenetic Reader Domain
• Solubility: DMSO:32.1 mg/mL (99.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.22 mM)

Bioactivity

• Target IC50:
  SMARCA2B:72 nM(Kd)|SMARCA4:55 nM(Kd)|SMARCA2A:110 nM(Kd)
• In Vitro:
  PFI-3 shows a significant selectivity for PB1(5) and SMARCA2/4 over 36 other tested kinases.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PB1(5) bromodomains, inhibit, Inhibitor, Epigenetic Reader Domain, EpigeneticReaderDomain, SMARCA2, SMARCA4, PFI 3, PFI3, PFI-3

Compound Identifiers

PubChem CID

78243717