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PFI-3

SKU: orb1300329

Description

PFI-3 is a potent and selective chemical probe targeting the bromodomains of SMARCA2/4 and PB1 proteins with a Kd of 89 nM. It is widely used in vitro and in vivo to investigate epigenetic mechanisms in oncology, particularly for studying potential therapeutic strategies in breast cancer models.

Research Area

Epigenetics & Chromatin, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1819363-80-8
MW321.4
Purity>98%
FormulaC19H19N3O2
SMILES[H][C@@]12CN(c3ccccn3)[C@@]([H])(CN1\C=C\C(=O)c1ccccc1O)C2
TargetBromodomain
SolubilitySoluble in DMSO (up to at least 25 mg/ml)

Bioactivity

Target IC50
SMARCA2B:72 nM(Kd)|SMARCA4:55 nM(Kd)|SMARCA2A:110 nM(Kd)
In Vitro
PFI-3 shows a significant selectivity for PB1(5) and SMARCA2/4 over 36 other tested kinases.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PB1(5) bromodomains, inhibit, Inhibitor, Epigenetic Reader Domain, EpigeneticReaderDomain, SMARCA2, SMARCA4, PFI 3, PFI3, PFI-3

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Key Properties

No computed properties available.

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PFI-3 (orb1300329)

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5 mg
$ 190.00
25 mg
$ 370.00
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