PF429242 dihydrochloride

SKU: orb1309257

Description

PF429242 dihydrochloride is a reversible S1P inhibitor with an IC50 of 175 nM. This compound is a valuable research tool for studying sphingosine-1-phosphate signaling in both cellular assays and animal models of inflammation and autoimmunity.

Research Area

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2248666-66-0
• MW: 482.49
• Purity: 99.68% (May vary between batches)
• Formula: C₂₅H₃₇Cl₂N₃O₂
• SMILES: Cl.Cl.CCN(CC)Cc1ccc(cc1)C(=O)N(CCc1ccccc1OC)[C@@H]1CCNC1
• Target: S1P Receptor,Virus Protease,Fatty Acid Synthase
• Solubility: DMSO:83.3 mg/mL (172.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.84 mM);H2O:50 mg/mL (103.63 mM)

Bioactivity

• Target IC50:
  S1P:175 nM
• In Vivo:
  PF-429242 inhibits the expression of hepatic SREBP target genes, and the hepatic rates of cholesterol and fatty acid synthesis are reduced In mice.
• In Vitro:
  10 μM PF-429242 down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC50 of 0.5 μM. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells. PF-429242 has potent antiviral against LCMV and LASV .

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Fatty Acid Synthase (FASN), inhibit, S1PReceptor, S1P Receptor, S1P, PF-429242, PF429242, PF429242 dihydrochloride, PF429242 Dihydrochloride, PF-429242 Dihydrochloride, PF-429242 dihydrochloride, PF 429242, PF 429242 Dihydrochloride, Virus Protease

Compound Identifiers

PubChem CID

90488837