PF429242 dihydrochloride

SKU: orb1940773

Description

PF429242 dihydrochloride can reversibly inhibit S1P (IC50 of 175 nM).(In Vitro):10 μM PF-429242 down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC50 of 0.5 μM. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells. PF-429242 has potent antiviral against LCMV and LASV .(In Vivo):PF-429242 inhibits the expression of hepatic SREBP target genes, and the hepatic rates of cholesterol and fatty acid synthesis are reduced In mice.

Key Properties

• CAS Number: 2248666-66-0
• MW: 482.49
• Purity: >98% (HPLC)
• Formula: C₂₅H₃₇Cl₂N₃O₂
• SMILES: O=C(N(CCC1=CC=CC=C1OC)[C@H]2CNCC2)C3=CC=C(CN(CC)CC)C=C3.[H]Cl.[H]Cl
• Target: S1P Receptor
• Solubility: In Vitro: DMSO : ≥ 83.3 mg/mL (172.65 m)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

S1P Receptor