PF-9363

SKU: orb1298315

Description

PF-9363 (CTX-3648) is a highly selective small molecule inhibitor of the histone acetyltransferases KAT6A and KAT6B. It is a research tool for investigating the role of these epigenetic regulators in cancer biology, with studies demonstrating its activity in both cellular and animal models of leukemia and solid tumors.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2569009-58-9
• MW: 444.46
• Purity: 99.70% (May vary between batches)
• Formula: C₂₀H₂₀N₄O₆S
• SMILES: COc1cccc(OC)c1S(=O)(=O)Nc1noc2cc(Cn3cccn3)cc(OC)c12
• Target: Histone Acetyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.5 mM);DMSO:55 mg/mL (123.75 mM)

Bioactivity

• In Vivo:
  PF-9363 exihibits strong anti-tumor activity in patient-derived xenograft models.
• In Vitro:
  PF-9363 (0~1 μM; 1 day) down-regulates the expression of the H3K23Ac biomarker in ZR75-1, T47D, and MCF7 cells and downregulates specific genes involved in the ESR1 pathway, cell cycle, and stem cell pathways. The IC50 values of PF-9363 for ZR75-1 and T47D are 0.3 nM and 0.9 nM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

xenograft, selective, PF9363, PF-9363, potent, PF 9363, HATs, HAT, HistoneAcetyltransferase, Histone Acetyltransferase, patient-derived, KAT6A/KAT6B, inhibit, Inhibitor, anti-tumor, cancer, CTX-3648, CTx648, CTx-648, CTX3648, CTX 3648, CTx 648

Compound Identifiers

PubChem CID

155411202