PF-9363

SKU: orb1218267

Description

PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.

Key Properties

• CAS Number: 2569009-58-9
• MW: 444.46
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₀N₄O₆S
• SMILES: O=S(C1=C(OC)C=CC=C1OC)(NC2=NOC3=C2C(OC)=CC(CN4N=CC=C4)=C3)=O
• Target: Histone Demethylase
• Solubility: In Vitro: DMSO : 50 mg/mL (112.50 mM)

Bioactivity

• In Vivo:
  PF-9363 shows strong anti-tumor activity in patient-derived xenograft models.
• In Vitro:
  PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker. PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM. Western blot analysis. Cell line: ZR75-1, T47D and MCF7 cells. Concentration: 0~1 μM. Incubation time: 1 day. Result: Down-regulated the expression of H3K23Ac biomarker.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CTX-3648

Quick Database Links

Gene Symbol

Histone Demethylase