PF-4840154

SKU: orb1302900

Description

PF-4840154 is a potent and selective agonist of both rat and human TRPA1 channels, with EC50 values of 97 nM and 23 nM, respectively. It induces TRPA1-mediated nocifensive behavior in mice, making it a valuable tool for studying pain and neurogenic inflammation in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1332708-14-1
• MW: 466.62
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₃₈N₆O₂
• SMILES: CC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(CC2CCCOC2)CC1
• Target: TRP/TRPV Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.14 mM);DMSO:4.67 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  TRPA1 (rat):97 nM|TRPA1 (human):23 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

behavior, hTRPA1, inhibit, Inhibitor, non-electrophilic, licking, nocifensive, rTRPA1, PF 4840154, PF4840154, PF-4840154, TRPVChannel, TRPChannel, TRPV Channel, TRP Channel, Transient receptor potential channels

Compound Identifiers

PubChem CID

53380803