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PF-4840154

SKU: orb1223343

Description

PF-4840154 is a non-electrophilic reference agonist of the TrpA1 channel. The TRPA1 channel is considered an attractive pain target based on the fact that TRPA1 knockout mice showed near complete attenuation of pain behaviors in some pre-clinical development models.

Images & Validation

Key Properties

CAS Number1332708-14-1
MW466.63
Purity>98% (HPLC)
FormulaC26H38N6O2
SMILESCC(C)CNc2nc(ncc2C(=O)NCc1ccccc1)N3CCN(CC3)CC4CCCOC4
TargetrTRPA1|hTRPA1
SolubilityDMSO : 50 mg/mL. 107.15 mM;

Bioactivity

In Vivo
PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse. Animal model: Female CD1 mice (25-30g) (In TrpA1+/+ mice). Dosage: 30 nmol. Administration: Intraplantar (i. pl) injection. Result: Elicited robust licking behavior.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PF-4840154 | PF 4840154 | PF4840154

Similar Products

  • PF-4840154 [orb1302900]

    >99.99% (May vary between batches)

    1332708-14-1

    466.62

    C26H38N6O2

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

PF-4840154 (orb1223343)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

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200 mg
500 mg
2 mg
$ 240.00
5 mg
$ 470.00
10 mg
$ 670.00
25 mg
$ 1,040.00
50 mg
$ 1,470.00
100 mg
$ 1,970.00