PF-06928215

SKU: orb1309258

Description

PF-06928215 is a potent small molecule inhibitor of the cGAS enzyme, demonstrating an IC50 of 4.9 µM. It is a valuable research tool for investigating the cGAS-STING signaling pathway in both cellular and animal models of autoimmunity, viral infection, and cancer.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2378173-15-8
• MW: 380.4
• Purity: 98.95% (May vary between batches)
• Formula: C₂₀H₂₀N₄O₄
• SMILES: OC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1cnn2c(O)cc(nc12)-c1ccccc1
• Target: cGAS
• Solubility: DMSO:33.33 mg/mL (87.62 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.63 mM)

Bioactivity

• Target IC50:
  cGAS:4.9 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclic GMP-AMP Synthase, cGAS, inhibit, Inhibitor, PF 06928215, PF06928215, PF-06928215

Compound Identifiers

PubChem CID

137300622