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PF-04971729

SKU: orb1226790

Description

A potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2; shows >2000-fold selectivity over hSGLT1; demonstrates robust urinary glucose excretion in rats and an excellent preclinical safety profile.Diabetes Phase 3 Clinical(In Vitro):Ertugliflozin (PF-04971729) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro.(In Vivo):Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats.

Images & Validation

Key Properties

CAS Number1210344-57-2
MW436.8827
Purity>98% (HPLC)
FormulaC22H25ClO7
SMILESO[C@@H]1[C@](O2)(CO)CO[C@]2(C3=CC=C(Cl)C(CC4=CC=C(C=C4)OCC)=C3)[C@H](O)[C@H]1O
TargetSGLT
SolubilityDMSO: ≥ 46 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Ertugliflozin | MK-8835 | PF-4971729

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Protocol Information

PF-04971729 (orb1226790)

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% DMSO +
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Available Sizes

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5 mg
$ 90.00
10 mg
$ 110.00
50 mg
$ 150.00
100 mg
$ 200.00
200 mg
$ 310.00
500 mg
$ 490.00