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PF 03716556

SKU: orb1223623

Description

PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.

Images & Validation

Key Properties

CAS Number928774-43-0
MW394.48
Purity>98% (HPLC)
FormulaC22H26N4O3
SMILESCC1=C2[C@@H](CCOC2=CC=C1)NC3=CC(=CN4C3=NC(=C4)C)C(=O)N(C)CCO
TargetATPase
SolubilityEthanol: 79 mg/mL (200.26 mM); DMSO: 79 mg/mL (200.26 mM)

Bioactivity

In Vivo
Animal model: Male Sprague-Dawley rats (250-300 g) treated with Pentagastrin. Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg. Administration: Intraduodenal administration; once. Result: Inhibited gastric acid secretion in a dose-dependent manner.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

PF 03716556 (orb1223623)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

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100 mg
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5 mg
$ 110.00
10 mg
$ 150.00
25 mg
$ 270.00
50 mg
$ 490.00