Perindoprilat

SKU: orb1223537

Description

Perindoprilat is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of perindoprilat is as an Angiotensin-converting Enzyme Inhibitor.

Key Properties

• CAS Number: 95153-31-4
• MW: 340.41
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₈N₂O₅
• SMILES: O=C([C@H]1N(C([C@H](C)N[C@H](C(O)=O)CCC)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O
• Target: AChR
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment improves cardiac function in mice with acute myocardial infarction and reduces the number of apoptotic myocardial cells. Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment reduces the expression levels of myocardial Bax and Bcl-2 in infarction zones of mice with acute myocardial infarction. Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment lowers the expression of myocardial TLR4/NF-κB in infarction zones in mice with acute myocardial infarction. Animal model: C57BL/6J mice underwent coronary ligation. Dosage: 1.5 mg/kg. Administration: Oral gavage; 1.5 mg/kg; once daily; 7 days. Result: Exhibited markedly lowered the number of apoptotic myocardial cells in comparison with the acute myocardial infarction group (p<0.05). Animal model: C57BL/6J mice underwent coronary ligation. Dosage: 1.5 mg/kg. Administration: Oral gavage; 1.5 mg/kg; once daily; 7 days. Result: Reduced the gene and protein expression levels of Bax (a myocardial apoptosis gene) in infarction zones in mice with acute myocardial infarction. Animal model: C57BL/6J mice underwent coronary ligation. Dosage: 1.5 mg/kg. Administration: Oral gavage; 1.5 mg/kg; once daily; 7 days. Result: Declined the number of stained NF-κB p50 protein in the nucleus in infarction zones (p<0.05), compared to the acute myocardial infarction group.
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• In Vitro:
  Perindoprilat (1 μM, 10 days) treatment suppresses the angiotensin II production in HNSCC cells. Perindoprilat (40 μM, 3 days) treatment attenuates mesangial cell fibronectin level. Cell Viability Assay Cell line: HNSCC cells. Concentration: 1 μM. Incubation time: 10 days. Result: Suppressed the angiotensin II production in HNSCC cells (P=0.028). Cell Viability Assay Cell line: Human mesangial cells. Concentration: 40 μM. Incubation time: 3 days. Result: Resulted in decreases in MPCM-stimulated fibronectin levels of 19.4±0.6% (P<0.001) and 21.7±1.0% (P<0.001) for secreted and cell-associated fibronectin levels, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S-9780

Quick Database Links

Gene Symbol

AChR