Perindopril erbumine

SKU: orb1227039

Description

PERINDOPRIL ERBUMINE is an angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.

Key Properties

• CAS Number: 107133-36-8
• MW: 441.61
• Purity: >98% (HPLC)
• Formula: C₂₃H₄₃N₃O₅
• SMILES: CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O.CC(C)(C)N
• Target: MRP
• Solubility: Ethanol: 88 mg/mL (199.27 mM); Water: 88 mg/mL (199.27 mM)

Bioactivity

• In Vivo:
  Animal model: Adenine-induced chronic kidney disease rats. Dosage: 0.1 mg/kg. Administration: Oral gavage (p.o.). Result: Abolished the LPS-induced astroglial and microglial activation. Attenuated LPS-induced TNF-α production. Prevented LPS-induced nuclear translocation of NF-кB. Prevented the AT1R up-regulation and the LPS-induced decrease in the expression of PP2A. Animal model: Chronic kidney disease rats. Dosage: 0.42 mg/kg. Administration: Oral. Result: Obviously reduced serum creatinine (Scr) and blood urea nitrogen (BUN) levels. Displayed a marked reduction of tubulointerstitial fibrosis. Exhibited more inhibitory effect on Col-IV expression and a exceed effect of raising OPA-1 expression. Significantly increased Sirtuin3 expression.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MRP