Pergolide mesylate salt

SKU: orb1224311

Description

PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat parkinson disease and hyperprolactinemiabut withdrawn from some markets due to potential for heart valve diseases.(In Vitro):Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process.(In Vivo):Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance .

Key Properties

• CAS Number: 66104-23-2
• MW: 410.59
• Purity: >98% (HPLC)
• Formula: C₂₀H₃₀N₂O₃S₂
• SMILES: [H][C@@]1(N(CCC)C[C@H](CSC)C[C@@]12[H])CC3=CNC4=C3C2=CC=C4.CS(=O)(O)=O
• Target: 5-HT Receptor
• Solubility: DMSO 10 mg/mL;Water 82 mg/mL

Bioactivity

• In Vivo:
  Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance. Animal model: Wistar rats (200-250 g) induced with 6-hydroxydopamine (6-OHDA). Dosage: 0.3 mg/kg. Administration: Intraperitoneal injection; daily; 11 days. Result: A reduced number of working/reference memory errors was observed. And significant decreased of MDA level.
• In Vitro:
  Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process. TCell Viability Assay Cell line: SH-SY5Y cells. Concentration: 0.01 μM, 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, 50 μM Incubation time: Pretreated for 2 hours. Result: Dose-dependently inhibited H2O2-induced cell death in SH-SY5Y neuroblastoma cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY127809 | NSC 319773

Quick Database Links

Gene Symbol

5-HT Receptor