PERFORIN (M) Antibody, Rabbit Polyclonal

SKU: orb67011

Description

Rabbit polyclonal to PERFORIN.PERFORIN (PRF1) is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Upondegranulation, PERFORIN inserts itself into the target cell's plasma membrane, forming a pore. Thelytic membrane-inserting part of PERFORIN is the MACPF domain, which shares homology withcholesterol-dependent cytolysins from Gram-positive bacteria. PERFORIN has structural andfunctional similarities to complement component 9 (C9). Like C9, PERFORIN creates transmembranetubules and is capable of lysing non-specifically a variety of target cells. PERFORIN is one of themain cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cellandnatural killer-cell-mediated cytolysis. Defects in PERFORIN cause familial hemophagocyticlymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.

Research Area

Cancer, Developmental Biology, Epigenetics

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:5000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: middle region of mouse PERFORIN
• Molecular Weight: 62
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-PERFORIN antibody,anti-Cytolysin antibody,anti-Lymphocyte poreforming protein antibody,anti-P1 antibody,anti-PRF1 antibody,anti-PFP antibody

Quick Database Links

UniProt

P31240