Pentamidine

SKU: orb1305716

Description

Pentamidine is an antifungal and antiprotozoal agent that binds the minor groove of AT-rich duplex DNA, inhibiting replication. It is widely used in research for studying trypanosomiasis, Pneumocystis pneumonia, and other infections in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 100-33-4
• MW: 340.42
• Purity: 98.13% (May vary between batches)
• Formula: C₁₉H₂₄N₄O₂
• SMILES: C(=N)(N)C1=CC=C(OCCCCCOC2=CC=C(C(=N)N)C=C2)C=C1
• Target: Antibiotic,Parasite,Antibacterial,Phosphatase,Antifungal
• Solubility: DMSO:Slightly soluble

Bioactivity

• Target IC50:
  Leishmania infantum:2.5 μM (IC50)
• In Vitro:
  Pentamidine is effective in therapy for the hemolymphatic stage of Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, arrest, Antibiotic, antitumor, antifungal, carinii, biosynthetics, cell-cycle, DNA, MP601205, MP-601205, MP 601205, Kidney, inhibit, Parasite, Fungal, Inhibitor, PTP1B, Pneumocystis, pneumonia, Pentamidine, Phosphatase

Compound Identifiers

PubChem CID

4735