Pentamidine dihydrochloride

SKU: orb1305717

Description

Pentamidine dihydrochloride

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 50357-45-4
• MW: 413.34
• Purity: 99.80%
• Formula: C₁₉H₂₆Cl₂N₄O₂
• SMILES: NC(c(cc1)ccc1OCCCCCOc(cc1)ccc1C(N)=N)=N.Cl.Cl
• Target: Antibacterial,Antibiotic,Phosphatase,Parasite,Antifungal
• Solubility: DMSO:4.14 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  Leishmania infantum:2.5 μM
• In Vivo:
  Pentamidine at a tolerable dose markedly inhibited the growth of WM9 human melanoma tumors in nude mice coincident with the induction of tumor cell necrosis and is capable of inactivating ectopically expressed PRL-2 in the cancer cells.
• In Vitro:
  Pentamidine at its therapeutic doses inhibited recombinant PRL phosphatases in vitro and inactivated ectopically expressed PRLs in NIH3T3 transfectants with an effective duration more than 24 h after a pulse cell treatment.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA, cell-cycle, carinii, biosynthetics, Bacterial, arrest, antitumor, Antibiotic, Parasite, Pneumocystis, pneumonia, Kidney, Inhibitor, inhibit, Fungal, MP-601205, MP601205 Dihydrochloride, MP-601205 Dihydrochloride, MP-601205 dihydrochloride, MP601205, MP 601205, MP 601205 Dihydrochloride, PTP1B, Pentamidine, Pentamidine dihydrochloride, Pentamidine Dihydrochloride, Phosphatase

Compound Identifiers

PubChem CID

10431865