Pentabromophenol

SKU: orb1940539

Description

Pentabromophenol suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.(In Vitro):Following 18hr exposure of murine BV-2 cells, at dose levels resulting in ≥80% viability (10 and 40 μM), limited alterations in pro-inflammatory responses were observed however, changes were observed in mitochondrial respiration. Basal respiration, ATP-linked respiration, maximum respiration, basal glycolytic and compensatory glycolysis were altered by Pentabromophenol. Phagocytosis was decreased for Pentabromophenol and TBBPA. NLRP3 inflammasome activation was assessed using BV-2-ASC (apoptosis-associated speck-like protein containing a CARD) reporter cells to visualize aggregate formation. Pentabromophenol, showed a direct stimulation of aggregate formation and properties as a NLRP3 inflammasome secondary trigger.

Key Properties

• CAS Number: 608-71-9
• MW: 488.593
• Purity: >98% (HPLC)
• Formula: C₆HBr₅O
• SMILES: Oc1c(Br)c(Br)c(Br)c(Br)c1Br
• Target: TGFBR

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 5717 | NSC-5717 | NSC5717

Quick Database Links

Gene Symbol

TGFBR