Pentabromophenol

SKU: orb1306697

Description

Pentabromophenol (NSC-5717) is a small molecule inhibitor of TGF-β signaling that acts by enhancing the degradation of TGF-β receptors. This mechanism makes it a useful research tool for studying TGF-β pathways in both cellular and biochemical assays.

Research Area

Cell Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 608-71-9
• MW: 488.59
• Purity: 98.89%
• Formula: C₆HBr₅O
• SMILES: Oc1c(Br)c(Br)c(Br)c(Br)c1Br
• Target: Apoptosis,TGF-beta/Smad
• Solubility: DMSO:4.89 mg/mL (10.01 mM)

Bioactivity

• In Vitro:
  Following 18hr exposure of murine BV-2 cells, at dose levels resulting in ≥80% viability (10 and 40 μM), limited alterations in pro-inflammatory responses were observed however, changes were observed in mitochondrial respiration. Basal respiration, ATP-linked respiration, maximum respiration, basal glycolytic and compensatory glycolysis were altered by Pentabromophenol. Phagocytosis was decreased for Pentabromophenol and TBBPA. NLRP3 inflammasome activation was assessed using BV-2-ASC (apoptosis-associated speck-like protein containing a CARD) reporter cells to visualize aggregate formation. Pentabromophenol, showed a direct stimulation of aggregate formation and properties as a NLRP3 inflammasome secondary trigger.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC5717, NSC-5717, NSC 5717, Smad, TGFb, TGF-b/Smad, TGFβ, TGF-β/Smad, TGFbeta/Smad, TGF-beta, TGFbeta, Pentabromophenol

Compound Identifiers

PubChem CID

11852