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Pemigatinib (INCB054828)

SKU: orb1220252

Description

Pemigatinib (INCB054828) is an orally active, selective FGFR inhibitor with IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1513857-77-6
MW487.5
Purity>98% (HPLC)
FormulaC??H??F?N?O?
SMILESCCN(C(N(C(C(F)=C(OC)C=C1OC)=C1F)C2)=O)C(C2=CN3)=C4C3=NC(CN5CCOCC5)=C4
TargetFGFR
SolubilityDMSO : 25 mg/mL (51.28 mM; ultrasonic and warming and heat to 60°C)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

INCB054828

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Protocol Information

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200 mg
500 mg
5 mg
$ 170.00
10 mg
$ 260.00
25 mg
$ 460.00
50 mg
$ 710.00
100 mg
$ 930.00