Pemigatinib

SKU: orb1309272

Description

Pemigatinib is a potent and selective oral inhibitor of fibroblast growth factor receptors, with the highest activity against FGFR1-3. It is used in preclinical and clinical research for studying cancers driven by FGFR alterations, demonstrating efficacy in both cellular assays and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1513857-77-6
• MW: 487.5
• Purity: 99.95% (May vary between batches)
• Formula: C₂₄H₂₇F₂N₅O₄
• SMILES: O=C(N1CC)N(C2=C(F)C=C(OC)C(OC)=C2F)CC3=C1C4=C(N=C3)NC(CN5CCOCC5)=C4
• Target: FGFR
• Solubility: DMSO:26.58 mg/mL (54.52 mM);10% DMSO+90% Saline:0.1 mg/mL (0.21 mM)

Bioactivity

• Target IC50:
  FGFR2:0.5 nM|FGFR3:1.2 nM|FGFR4:30 nM|FGFR1:0.4 nM
• In Vitro:
  In cells expressing FGFR2-CLIP1 fusion are sensitive to Pemigatinib (INCB054828; IC50 value of 10.16 nM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cholangiocarcinoma, antineoplastic, FGFR4, FGFR3, FGFR2, FGFR1, Fibroblast growth factor receptor, FGFR, Inhibitor, inhibit, INCB054828, INCB-054828, INCB 054828, Orally, Pemigatinib

Compound Identifiers

PubChem CID

86705695