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Catalog Number | orb1731540 |
---|---|
Category | Antibodies |
Description | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). |
Species/Host | Rabbit |
Clonality | Monoclonal |
Tested applications | IP, WB |
Reactivity | Human, Rat |
Isotype | Rabbit IgG |
Immunogen | Recombinant protein of human Pellino 1 |
Concentration | 1mg/ml |
Dilution range | IP: 1/20; WB: 1/500-1/1000 |
Conjugation | Unconjugated |
MW | Calculated MW: 46 kDa; Observed MW: 46 kDa |
Entrez | 57162 |
UniProt ID | Q96FA3 |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Buffer/Preservatives | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% rAlbumin |
Alternative names | Pellino-related intracellular-signaling molecule; Read more... |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
ELISA, ICC, IF, WB | |
Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
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